In the News & HPV Research

Dermatologic Therapy (clearance rates up to 77% and low recurrence rates)
Therapy of cutaneous human Papillomavirus infections
http://onlinelibrary.wiley.com/doi/10.1111/j.1396-0296.2004.04047.x/full

ScienceDirect: Therapeutic Approaches to Genital Warts

HIGHLIGHT: "... Therapeutic options include chemotherapeutic agents, cryotherapy and surgery, but all these treatments are anti-tumor, not anti-viral. Interferons (IFNs) are the only anti-viral drugs approved for the therapy of benign HPV-related lesions..." [more]

An evidence-base review of medical and surgical treatments of genital warts

HIGHLIGHT: "... Interferon can be injected locally or administered systemically to treat genital warts..." [more]

CDC STD Treatment Guidelines

HIGHLIGHTS: "... A limited number of case reports of severe systemic effects resulting from treatment with podophyllin resin and interferon have been documented. Treatment regimens are classified into patient-applied and provider-applied modalities. Patient-applied modalities are preferred by some patients because they can be administered in the privacy of the patient’s home... Alternative regimens include treatment options that might be associated with more side effects and/or less data on efficacy. Alternative regimens include intralesional interferon, photodynamic therapy, and topical cidofovir..." [more]

Aetna Interferons NO: 0404

HIGHLIGHT:"... Aetna considers interferon alfa-N3 (Alferon N) medically necessary for intralesional treatment of refractory or recurring external condylomata acuminata (venereal/genital warts)..." [more]

 

Interferons alpha, beta and gamma therapy of anogenital human papillomavirus infections

HIGHLIGHT: "... These three groups of IFNs have been used successfully as monotherapy or in combination with traditional modalities to treat anogenital condyloma acuminatum." [more]

 

Interferon as an adjuvant treatment for genital condyloma acuminatum

HIGHLIGHT: " ...  Interferon is effective as adjuvant treatment in controlling the recurrence of genital HPV." [more]

Treatment of men with flat (FC) or acuminata (CA) condylomata with interferon alpha-2a

HIGHLIGHT: "...  In conclusion we believe that IFN alpha-2a can be used with excellent results as first line treatment in combination with CO2 laser vaporization or/plus 5-FU in patients with C.A. or F.C. or combined condylomata." [more]

Interferon Is Used For Genital Warts
New York Times

HIGHLIGHTS: "... Injections of the germ-fighting hormone interferon appear to be a promising new treatment for genital warts, one of the nation's most common venereal disease problems, researchers said today... 'This is the first time that interferon has been shown by multiple investigators to be effective,' said Dr. Lawrence Eron of Fairfax Hospital in Falls Church, Va... 'There is no question in my mind that interferon has a part to play in the treatment of genital warts,' Dr. Eron said... Dr. Alvin Friedman-Kien, who conducted another of the studies at New York University, said, 'I've treated warts for 25 years and worked with all sorts of other treatment modalities, and I think the response in the treatment trial that we've done is rather remarkable.''' [more]

Human Papillomavirus Treatment & Management
Medscape

HIGHLIGHTS: "... Interferons have been used in the United States for the treatment of genital warts in various doses and preparations. Topical, intralesional, and systemic therapy have been used. Currently, no convincing evidence suggests that topical or systemic therapy is better than placebo... Local injection of interferon appears to be more effective than systemic injection... The maximum response usually occurs 4-8 weeks after initiation of the first treatment course... Patients with 6-10 condylomata may receive a second (sequential) course of treatment using the same dosage schedule to treat up to 5 additional condylomata per course of treatment. Patients with more than 10 condylomata may receive additional sequences, depending on how many condylomata are present..." [more]

Condylomata Acuminata (anogenital warts)

HIGHLIGHTS: “Local or systemic treatment with interferon may also decrease the likelihood of recurrence following surgical excision or ablative therapy, but is uncommonly used in clinical practice…” [more]

Adjuvant interferon for anal condyloma

HIGHLIGHT: “Adjuvant interferon treatment can reduce the high recurrence rate of anal condyloma seen after surgical extirpation…” [more]

Condylomata Acuminata (anogenital warts)

HIGHLIGHT: “Local or systemic treatment with interferon may also decrease the likelihood of recurrence following surgical excision or ablative therapy, but is uncommonly used in clinical practice…” [more]

Local administration of interferon-alpha in cases of cervical intraepithelial neoplasia associated with human papillomavirus infection.

HIGHLIGHT: “These results suggest that treatment with interferon-alpha is an effective therapeutic method for CIN associated with HPV infection, and 10 administrations of 3 mIU constitute the optimal dose.” [more]